If the chain is not being used for a high wear application (for instance if it is just transmitting motion from a hand operated lever to a control shaft on a machine, or a sliding door on an oven), then one of the simpler types of chain may still be used. Conversely, where extra strength but the smooth drive of a smaller pitch is required, the chain may be "siamesed"; instead of just two rows of plates on the outer sides of the chain, there may be three ("duplex"), four ("triplex"), or more rows of plates running parallel, with bushings and rollers between each adjacent pair, and the same number of rows of teeth running in parallel on the sprockets to match. Timing chains on automotive engines, for example, typically have multiple rows of plates called strands.

Roller chain is made in several sizes, the most common American National Standards Institute (ANSI) standards being 40, 50, 60, and 80. The first digit(s) indicate the pitch of the chain in eighths of an inch, with the last digit being 0 for standard chain, 1 for lightweight chain, and 5 for bushed chain with no rollers. Thus, a bicycle chain with half inch pitch would be a #40 while a #160 sprocket would have teeth spaced 2 inches apart, etc. Metric pitches are expressed in sixteenths of an inch; thus a metric #8 chain (08B-1) would be equivalent to an ANSI #40. Most roller chain is made from plain carbon or alloy steel, but stainless steel is used in food processing machinery or other places where lubrication is a problem, and nylon or brass are occasionally seen for the same reason.

Roller chain is ordinarily hooked up using a master link (also known as a connecting link), which typically has one pin held by a horseshoe clip rather than friction fit, allowing it to be inserted or removed with simple tools. Half links (also known as offsets) are available and are used to increase the length of the chain by a single roller.